MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)

Stable Identifier
R-HSA-901074
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum quality control compartment
Synonyms
Trimming of the terminal mannose on the B branch
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the B position (Gonzalez et al. 1999, Karaveg et al. 2005, Avezov et al. 2008). The ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) is also able to hydrolyse the alpha-1,2-mannose from (GlcNAc)2 (Man)9 to form (GlcNAc)2 (Man)8b (Ninagawa et al. 2014).

Literature References
PubMed ID Title Journal Year
18003979 Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation

Herscovics, A, Ehrlich, M, Lederkremer, GZ, Avezov, E, Frenkel, Z

Mol Biol Cell 2008
10409699 Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis

Karaveg, K, Gonzalez, DS, Moremen, KW, Lal, A, Vandersall-Nairn, AS

J Biol Chem 1999
15713668 Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control

Liu, ZJ, Karaveg, K, Moremen, KW, Glushka, J, Tempel, W, Wang, BC, Siriwardena, A

J. Biol. Chem. 2005
25092655 EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Kamiya, Y, Takeda, S, Ishikawa, T, Sakuma, T, Sumitomo, Y, Okada, T, Yamamoto, T, Horimoto, S, Mori, K, Ninagawa, S, Kato, K

J. Cell Biol. 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
trimming of terminal mannose on B branch (0036509)
Catalyst Activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]

Physical Entity
MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment] (Homo sapiens)
Activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-11-18)
Created
Jassal, B  (2010-07-02)
Cite Us!