MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)

Stable Identifier
R-HSA-901074
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Trimming of the terminal mannose on the B branch
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The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the B position (Gonzalez et al. 1999, Karaveg et al. 2005, Avezov et al. 2008). The ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) is also able to hydrolyse the alpha-1,2-mannose from (GlcNAc)2 (Man)9 to form (GlcNAc)2 (Man)8b (Ninagawa et al. 2014).

Literature References
PubMed ID Title Journal Year
10409699 Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis

Gonzalez, DS, Karaveg, K, Vandersall-Nairn, AS, Lal, A, Moremen, KW

J Biol Chem 1999
18003979 Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation

Avezov, E, Frenkel, Z, Ehrlich, M, Herscovics, A, Lederkremer, GZ

Mol Biol Cell 2008
15713668 Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control

Karaveg, K, Siriwardena, A, Tempel, W, Liu, ZJ, Glushka, J, Wang, BC, Moremen, KW

J. Biol. Chem. 2005
25092655 EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Ninagawa, S, Okada, T, Sumitomo, Y, Kamiya, Y, Kato, K, Horimoto, S, Ishikawa, T, Takeda, S, Sakuma, T, Yamamoto, T, Mori, K

J. Cell Biol. 2014
Participants
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Event Information
Catalyst Activity
Catalyst Activity
Title
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
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Activity
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Reviewed
Created