The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the B position (Gonzalez et al. 1999, Karaveg et al. 2005, Avezov et al. 2008). The ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) is also able to hydrolyse the alpha-1,2-mannose from (GlcNAc)2 (Man)9 to form (GlcNAc)2 (Man)8b (Ninagawa et al. 2014).
Gonzalez, DS, Karaveg, K, Vandersall-Nairn, AS, Lal, A, Moremen, KW
Avezov, E, Frenkel, Z, Ehrlich, M, Herscovics, A, Lederkremer, GZ
Karaveg, K, Siriwardena, A, Tempel, W, Liu, ZJ, Glushka, J, Wang, BC, Moremen, KW
Ninagawa, S, Okada, T, Sumitomo, Y, Kamiya, Y, Kato, K, Horimoto, S, Ishikawa, T, Takeda, S, Sakuma, T, Yamamoto, T, Mori, K
© 2021 Reactome