PKC phosphorylates ROBO3.1

Stable Identifier
R-HSA-9010681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PKC phosphorylates ROBO3.1
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PKC (PRKCA, and possibly other isoforms), recruited to ROBO3 receptor isoform ROBO3.1 by AKAP5 (AKAP79) phosphorylates ROBO3.1 on serine residue S1330 (Samelson et al. 2015).
Literature References
PubMed ID Title Journal Year
25882844 A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors

Samelson, BK, Gore, BB, Whiting, JL, Nygren, PJ, Purkey, AM, Colledge, M, Langeberg, LK, Dell'Acqua, ML, Zweifel, LS, Scott, JD

J. Biol. Chem. 2015
Participants
Input
Output
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as an event of
Catalyst Activity

calcium,diacylglycerol-dependent serine/threonine kinase activity of ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane]

Physical Entity
ROBO3.1:AKAP5:p-T497,T638,S657-PRKCA [plasma membrane] (Homo sapiens)
Activity
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Orthologous Events
PKC phosphorylates ROBO3.1 (Canis familiaris)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-27)
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