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HOXA2 binds ROBO2 gene promoter
Stable Identifier
R-HSA-9010503
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
HOXA2 binds ROBO2 gene promoter (Homo sapiens)
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Based on studies in mice, the homeobox transcription factor HOXA2 binds to an evolutionarily conserved (also present in the human gene) HOX-PBX binding site in the second intron of the ROBO2 gene (Geisen et al. 2008). The heterodimerization partner of HOXA2 at the ROBO2 gene binding site is not known.
Participants
Input
HOXA2 [nucleoplasm]
(Homo sapiens)
ROBO2 gene [nucleoplasm]
(Homo sapiens)
Output
HOXA2:ROBO2 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Inferred From
Hoxa2 binds Robo2 gene (Mus musculus)
Authored
Orlic-Milacic, M (2017-06-23)
Reviewed
Jaworski, A (2017-07-31)
Created
Orlic-Milacic, M (2017-06-27)
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