Reactome | MAN1B1 hydrolyses 1,2-linked mannose (a branch)

MAN1B1 hydrolyses 1,2-linked mannose (a branch)

Stable Identifier

R-HSA-901024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum quality control compartment

Synonyms

Trimming of the first mannose on the A branch

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
      - Calnexin/calreticulin cycle (Homo sapiens)
        
        ER Quality Control Compartment (ERQC) (Homo sapiens)
        
        MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)

General

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MAN1B1 hydrolyses 1,2-linked mannose (a branch)

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the A position (Hirao et al, 2006; Frenkel et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
18003979	Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation Herscovics, A, Ehrlich, M, Lederkremer, GZ, Avezov, E, Frenkel, Z	Mol Biol Cell	2008
10409699	Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis Karaveg, K, Gonzalez, DS, Moremen, KW, Lal, A, Vandersall-Nairn, AS	J Biol Chem	1999
15713668	Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control Liu, ZJ, Karaveg, K, Moremen, KW, Glushka, J, Tempel, W, Wang, BC, Siriwardena, A	J. Biol. Chem.	2005