MAN1B1 hydrolyses 1,2-linked mannose (a branch)

Stable Identifier
R-HSA-901024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Trimming of the first mannose on the A branch
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The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the A position (Hirao et al, 2006; Frenkel et al, 2003).

Literature References
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
Physical Entity
Activity
Authored
Reviewed
Created