The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the A position (Hirao et al, 2006; Frenkel et al, 2003).
Herscovics, A, Ehrlich, M, Lederkremer, GZ, Avezov, E, Frenkel, Z
Karaveg, K, Gonzalez, DS, Moremen, KW, Lal, A, Vandersall-Nairn, AS
Liu, ZJ, Karaveg, K, Moremen, KW, Glushka, J, Tempel, W, Wang, BC, Siriwardena, A
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
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