Reactome | MAN1B1 hydrolyses 1,2-linked mannose (a branch)

MAN1B1 hydrolyses 1,2-linked mannose (a branch)

Stable Identifier

R-HSA-901024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum quality control compartment

Synonyms

Trimming of the first mannose on the A branch

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
      - Calnexin/calreticulin cycle (Homo sapiens)
        
        ER Quality Control Compartment (ERQC) (Homo sapiens)
        
        MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)

General

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MAN1B1 hydrolyses 1,2-linked mannose (a branch)

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The enzyme ER Man I can slowly trim up to four of the mannoses on the N-glycan on unfolded proteins accumulated in the ER. This step describes the removal of the mannose in the A position (Hirao et al, 2006; Frenkel et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
10409699	Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis Gonzalez, DS, Karaveg, K, Vandersall-Nairn, AS, Lal, A, Moremen, KW	J Biol Chem	1999
18003979	Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation Avezov, E, Frenkel, Z, Ehrlich, M, Herscovics, A, Lederkremer, GZ	Mol Biol Cell	2008
15713668	Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control Karaveg, K, Siriwardena, A, Tempel, W, Liu, ZJ, Glushka, J, Wang, BC, Moremen, KW	J. Biol. Chem.	2005

Participants

Input

Output

Participant Of

hasEvent

ER Quality Control Compartment (ERQC)

Event Information

Go Biological Process

trimming of first mannose on A branch (0036511)

Catalyst Activity

Title

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]

Physical Entity

MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]

Activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (0004571)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-11-18)

Created

Jassal, B (2010-07-02)