Binding of Malectin

Stable Identifier
R-HSA-901006
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Binding of Malectin
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A recently discovered protein called malectin is known to recognize the Glc(2)Man(9)GlcNAc(2) glycan (Schallus T et al, 2008). The exact role of this interaction is not clear but malectin is thought to regulate the availability of this substrate to glucosidase II, or to act as a chaperone to stabilize the unfolded protein.
Literature References
PubMed ID Title Journal Year
18524852 Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation

Liu, Y, Palma, AS, Simpson, JC, Muhle-Goll, C, Feizi, T, Gibson, TJ, Stier, G, Pieler, T, Schallus, T, Mackeen, M, Fehér, K, Jaeckh, C

Mol Biol Cell 2008
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Output
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as an event of
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-08-17)
Created
Jassal, B  (2010-07-02)
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