ADAM10:Zn2+:TSPANs cleaves APP(18-770)

Stable Identifier
R-HSA-9010034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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ADAM10:Zn2+:TSPANs cleaves APP(18-770)
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ADAM10 (A Disintegrin and Metalloproteinase 10) has been identified as the major physiological alpha-secretase in neurons (Lammich et al. 1999, Kuhn et al. 2010), responsible for cleaving amyloid precursor protein (APP(18-770)) in a non-amyloidogenic manner and producing APPs-alpha (APP(18-687), a neuroprotective APP-derived peptide (Mockett et al. 2017, Endres & Deller 2017). This cleavage also produces a cellular fragment, C83/CTF-alpha (APP(688-770). Cleavage by alpha-secretase at the cell surface is the major pathway in APP processing, accounting for 80–90% of APP turnover.
Literature References
PubMed ID Title Journal Year
20676056 ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

Kuhn, PH, Wang, H, Dislich, B, Colombo, A, Zeitschel, U, Ellwart, JW, Kremmer, E, Rossner, S, Lichtenthaler, SF

EMBO J. 2010
10097139 Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

Lammich, S, Kojro, E, Postina, R, Gilbert, S, Pfeiffer, R, Jasionowski, M, Haass, C, Fahrenholz, F

Proc. Natl. Acad. Sci. U.S.A. 1999
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Catalyst Activity

metalloendopeptidase activity of ADAM10:Zn2+:TSPANs [plasma membrane]

Physical Entity
ADAM10:Zn2+:TSPANs [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Authored
Jassal, B  (2017-06-26)
Reviewed
Meras-Rios, A  (2018-08-10)
Created
Jassal, B  (2017-06-26)
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