ADAM10:Zn2+:TSPANs cleaves APP(18-770)

Stable Identifier
R-HSA-9010034
Type
Reaction [transition]
Species
Homo sapiens
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ADAM10 (A Disintegrin and Metalloproteinase 10) has been identified as the major physiological alpha-secretase in neurons (Lammich et al. 1999, Kuhn et al. 2010), responsible for cleaving amyloid precursor protein (APP(18-770)) in a non-amyloidogenic manner and producing APPs-alpha (APP(18-687), a neuroprotective APP-derived peptide (Mockett et al. 2017, Endres & Deller 2017). This cleavage also produces a cellular fragment, C83/CTF-alpha (APP(688-770). Cleavage by alpha-secretase at the cell surface is the major pathway in APP processing, accounting for 80–90% of APP turnover.

Literature References
PubMed ID Title Journal Year
10097139 Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

Lammich, S, Kojro, E, Postina, R, Gilbert, S, Pfeiffer, R, Jasionowski, M, Haass, C, Fahrenholz, F

Proc. Natl. Acad. Sci. U.S.A. 1999
20676056 ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

Kuhn, PH, Wang, H, Dislich, B, Colombo, A, Zeitschel, U, Ellwart, JW, Kremmer, E, Rossner, S, Lichtenthaler, SF

EMBO J. 2010
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Catalyst Activity
Title
metalloendopeptidase activity involved in amyloid precursor protein catabolic process of ADAM10:Zn2+:TSPANs [plasma membrane]
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