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p-Y-IL2RG [cytosol]
Stable Identifier
R-HSA-9009721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31785 IL2RG
Gene Names
IL2RG
Chain
signal peptide:1-22, chain:23-369
Reference Genes
BioGPS Gene:3561 IL2RG
COSMIC (genes):IL2RG IL2RG
CTD Gene:3561 IL2RG
dbSNP Gene:3561 IL2RG
ENSEMBL:ENSG00000147168 IL2RG
HGNC:6010 IL2RG
KEGG Gene (Homo sapiens):3561 IL2RG
Monarch:3561 IL2RG
NCBI Gene:3561 IL2RG
OMIM:308380 IL2RG
UCSC:P31785 IL2RG
Reference Transcript
RefSeq:NM_000206.2 IL2RG
Other Identifiers
0006550390
11720207_a_at
11753814_a_at
11753882_a_at
11753883_x_at
11754181_a_at
11754182_x_at
1506_at
17111895
1ILL
1ILM
1ILN
1ITE
204116_at
2B5I
2ERJ
3561
3BPL
3QAZ
3QB7
4011855
4011856
4011857
4011858
4011860
4011862
4011864
4011865
4011866
4011869
4011872
4011873
4011876
4011877
46641
49691
4GS7
5M5E
8173444
A_23_P148473
A_33_P3290394
AAA59145
AAC37524
AAH14972
AAT85803
AB102794
AL590764
AY692262
BAA01857
BAD89385
BC014972
CCDS14406
D11086
D11086_at
D6R964
D6RDW9
ENSG00000147168
ENSP00000363318
ENSP00000388967
ENST00000374202
ENST00000374202.6
ENST00000456850
ENST00000456850.6
EntrezGene:3561
EntrezGene:IL2RG
g4557881_3p_at
GE57049
GO:0000165
GO:0002376
GO:0003674
GO:0004896
GO:0004911
GO:0004913
GO:0004917
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006955
GO:0007165
GO:0008150
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0016032
GO:0016192
GO:0019221
GO:0019955
GO:0019976
GO:0031410
GO:0032991
GO:0035723
GO:0035771
GO:0038110
GO:0038111
GO:0038113
GO:0038114
GO:0042010
GO:0043226
GO:0043235
GO:0044403
GO:0050766
HGNC:6010
HPA046641
HPA049691
IL2RG
IL2RG-203
IL2RG-204
ILMN_1794386
IPR003531
IPR003961
IPR013783
IPR015321
IPR036116
L12176
L12177
L12178
L12179
L12180
L12181
L12182
L12183
L19546
LRG_150
LRG_150t1
MIM:300400
MIM:308380
MIM:312863
NM_000206
NP_000197
PF09240
PH_hs_0000012
Q5FC10
TC0X001121.hg
UPI0000000DEA
UPI00004CA0C1
Participant Of
hasComponent
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane]
Other forms of this molecule
IL2RG [endosome]
p-Y-IL2RG [plasma membrane]
IL2RG [plasma membrane]
Inferred To
Ghost homologue of p-Y-IL2RG [cytosol] (Xenopus tropicalis)
phospho-p-Y-IL2RG [cytosol] (Bos taurus)
phospho-p-Y-IL2RG [cytosol] (Canis familiaris)
phospho-p-Y-IL2RG [cytosol] (Danio rerio)
phospho-p-Y-IL2RG [cytosol] (Gallus gallus)
phospho-p-Y-IL2RG [cytosol] (Mus musculus)
phospho-p-Y-IL2RG [cytosol] (Rattus norvegicus)
phospho-p-Y-IL2RG [cytosol] (Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000197.1
OpenTargets
ENSG00000147168
GeneCards
P31785
PRO
P31785
Orphanet
16257
PDB
5M5E
,
1ILL
,
2B5I
,
1ILM
,
3QB7
,
1ITE
,
1ILN
,
6OEL
,
3QAZ
,
2ERJ
,
3BPL
,
4GS7
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24394 IL4R
2
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
IL4R [plasma membrane]
(R-HSA-449670)
0.667
5
UniProt:P05112 IL4
1
IL4 [extracellular region]
(R-HSA-447110)
0.667
3
UniProt:Q7Z3S9 NT2NA
0.666
4
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q13261 IL15RA
2
IL15RA [plasma membrane]
(R-HSA-449122)
IL15RA [endosome]
(R-HSA-8983117)
0.524
2
IntAct:EBI-11749135 KRTAP13
0.488
2
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.488
2
UniProt:Q96CG3 TIFA
2
p-T9-TIFA [cytosol]
(R-HSA-9645512)
TIFA [cytosol]
(R-HSA-451582)
0.488
2
UniProt:Q6L8G8 KRTAP5-7
1
KRTAP5-7 [cytosol]
(R-HSA-6810273)
0.488
2
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![p-Y-IL2RG [cytosol] icon](/icon/R-ICO-012880.svg){kind=icon}