IL34 dimer binds SDC1

Stable Identifier
R-HSA-9009558
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL34 dimer binds SDC1
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Interleukin-34 (IL34) is involved in the survival, proliferation and differentiation of monocytes and macrophages. Syndecan-1 (SDC1) is a cell surface proteoglycan that contains the chondroitin sulphate and primarily functions to link the cytoskeleton to the interstitial matrix. IL34 dimers can bind to the chondroitin sulphate of SDC1. Subsequently, SDC1 modulates IL34-induced CSF1R signaling pathways (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation.
Literature References
PubMed ID Title Journal Year
25662098 Syndecan-1 regulates the biological activities of interleukin-34

Ségaliny, AI, Mortier, E, Cherel, M, Maillasson, M, Heymann, D, Jacques, Y, Brion, R, Le Goff, B

Biochim. Biophys. Acta 2015
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Authored
Varusai, TM  (2017-06-20)
Reviewed
Meldal, BH  (2017-11-03)
Created
Varusai, TM  (2017-06-20)
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