Reactome | IL34 dimer:SDC1 binds CSF1R

IL34 dimer:SDC1 binds CSF1R

Stable Identifier

R-HSA-9009554

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell surface proteoglycan. Low levels of SDC1 may sequester IL34 at the cell surface and prevent it from binding Macrophage colony-stimulating factor 1 receptor (CSF1R), while high SDC1 levels may facilitate IL34-CSF1R signaling (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The precise interaction between IL34:SDC1 and CSF1R is unknown. Hence, this interaction is represented as an uncertain black box event.

Literature References

PubMed ID	Title	Journal	Year
25662098	Syndecan-1 regulates the biological activities of interleukin-34 Ségaliny, AI, Mortier, E, Cherel, M, Maillasson, M, Heymann, D, Jacques, Y, Brion, R, Le Goff, B	Biochim. Biophys. Acta	2015