ESR1 binds to TFF1 gene promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TFF1 is an estrogen-responsive gene with an ESR1-bound promoter/enhancer that is primed for ligand-dependent expression by the binding of 'pioneer' transcription factors, such as FOXA1 and GATA3 (Berry et al, 1989; Shang et al, 2000; Carroll et al, 2005; Laganière et al, 2005; Eeckhoute et al, 2006; Hurtado et al, 2011; Theodorou et al, 2013; reviewed in Klinge, 2001; Zaret and Carroll, 2011; Fiorito et al, 2013). Ligand-bound estrogen receptor binds to a functional ERE between -405 and -393 and to a region 10.5 kb upstream of the TFF1 transcription start site (Berry et al, 1989; Sewack and Hansen, 1997; Métivier et al, 2003; Carroll et al, 2005). Detailed ChIP studies of the TFF1 promoter in synchronized cells after estrogen stimulation reveal an ordered and cyclical recruitment of co-activators, chromatin remodellers and general transcriptional machinery that modify the epigenetic and chromatin environment to regulate transcriptional activity (Metivier et al, 2003; Metivier et al, 2008; Kangaspeska et al, 2008). Three phases are observed after estrogen stimulation of blocked cells, including an initial unproductive cycle followed by two transcriptionally productive cycles. These are marked by the combinatorial recruitment of different subsets of proteins and cyclical alterations to the methylation and acetylation status of the promoter (Metivier et al, 2003; Metivier et al, 2008; Kangaspeska et al, 2008; reviewed in Reid et al, 2009).

Literature References
PubMed ID Title Journal Year
11452016 Estrogen receptor interaction with estrogen response elements

Klinge, CM

Nucleic Acids Res. 2001
16980581 A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

Brown, M, Geistlinger, TR, Torres-Arzayus, MI, Eeckhoute, J, Carroll, JS

Genes Dev. 2006
18805503 Marking time: the dynamic role of chromatin and covalent modification in transcription

Reid, G, Métivier, R, Gallais, R

Int. J. Biochem. Cell Biol. 2009
23192763 Cooperating transcription factors mediate the function of estrogen receptor

Hurtado, A, Fiorito, E, Katika, MR

Chromosoma 2013
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
11136970 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA

Cell 2000
2919170 Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence

Chambon, P, Nunez, AM, Berry, M

Proc. Natl. Acad. Sci. U.S.A. 1989
16087863 From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G

Proc. Natl. Acad. Sci. U.S.A. 2005
18322535 Transient cyclical methylation of promoter DNA

Reid, G, Métivier, R, Kangaspeska, S, Carmouche, RP, Gannon, F, Stride, B, Ibberson, D, Polycarpou-Schwarz, M, Benes, V

Nature 2008
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Stark, R, Menon, S, Carroll, JS, Theodorou, V

Genome Res. 2013
17013392 Genome-wide analysis of estrogen receptor binding sites

Bekiranov, S, Hall, GF, Li, W, Fertuck, KC, Geistlinger, TR, Sementchenko, V, Liu, XS, Brodsky, AS, Meyer, CA, Silver, PA, Fox, EA, Brown, M, Wang, Q, Keeton, EK, Eeckhoute, J, Song, J, Gingeras, TR, Carroll, JS

Nat. Genet. 2006
9388265 Nucleosome positioning and transcription-associated chromatin alterations on the human estrogen-responsive pS2 promoter

Sewack, GF, Hansen, U

J. Biol. Chem. 1997
Orthologous Events
Cite Us!