Reactome | ESR1 binds to TFF1 gene promoter

ESR1 binds to TFF1 gene promoter

Stable Identifier

R-HSA-9009541

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TFF1 is an estrogen-responsive gene with an ESR1-bound promoter/enhancer that is primed for ligand-dependent expression by the binding of 'pioneer' transcription factors, such as FOXA1 and GATA3 (Berry et al, 1989; Shang et al, 2000; Carroll et al, 2005; Laganière et al, 2005; Eeckhoute et al, 2006; Hurtado et al, 2011; Theodorou et al, 2013; reviewed in Klinge, 2001; Zaret and Carroll, 2011; Fiorito et al, 2013). Ligand-bound estrogen receptor binds to a functional ERE between -405 and -393 and to a region 10.5 kb upstream of the TFF1 transcription start site (Berry et al, 1989; Sewack and Hansen, 1997; Métivier et al, 2003; Carroll et al, 2005). Detailed ChIP studies of the TFF1 promoter in synchronized cells after estrogen stimulation reveal an ordered and cyclical recruitment of co-activators, chromatin remodellers and general transcriptional machinery that modify the epigenetic and chromatin environment to regulate transcriptional activity (Metivier et al, 2003; Metivier et al, 2008; Kangaspeska et al, 2008). Three phases are observed after estrogen stimulation of blocked cells, including an initial unproductive cycle followed by two transcriptionally productive cycles. These are marked by the combinatorial recruitment of different subsets of proteins and cyclical alterations to the methylation and acetylation status of the promoter (Metivier et al, 2003; Metivier et al, 2008; Kangaspeska et al, 2008; reviewed in Reid et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
11452016	Estrogen receptor interaction with estrogen response elements Klinge, CM	Nucleic Acids Res.	2001
16980581	A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer Brown, M, Geistlinger, TR, Torres-Arzayus, MI, Eeckhoute, J, Carroll, JS	Genes Dev.	2006
18805503	Marking time: the dynamic role of chromatin and covalent modification in transcription Reid, G, Métivier, R, Gallais, R	Int. J. Biochem. Cell Biol.	2009
23192763	Cooperating transcription factors mediate the function of estrogen receptor Hurtado, A, Fiorito, E, Katika, MR	Chromosoma	2013
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR	Cell	2003
11136970	Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription Hu, X, Brown, M, DiRenzo, J, Shang, Y, Lazar, MA	Cell	2000
2919170	Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence Chambon, P, Nunez, AM, Berry, M	Proc. Natl. Acad. Sci. U.S.A.	1989
16087863	From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G	Proc. Natl. Acad. Sci. U.S.A.	2005
18322535	Transient cyclical methylation of promoter DNA Reid, G, Métivier, R, Kangaspeska, S, Carmouche, RP, Gannon, F, Stride, B, Ibberson, D, Polycarpou-Schwarz, M, Benes, V	Nature	2008
22056668	Pioneer transcription factors: establishing competence for gene expression Zaret, KS, Carroll, JS	Genes Dev.	2011
23172872	GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility Stark, R, Menon, S, Carroll, JS, Theodorou, V	Genome Res.	2013
17013392	Genome-wide analysis of estrogen receptor binding sites Bekiranov, S, Hall, GF, Li, W, Fertuck, KC, Geistlinger, TR, Sementchenko, V, Liu, XS, Brodsky, AS, Meyer, CA, Silver, PA, Fox, EA, Brown, M, Wang, Q, Keeton, EK, Eeckhoute, J, Song, J, Gingeras, TR, Carroll, JS	Nat. Genet.	2006
9388265	Nucleosome positioning and transcription-associated chromatin alterations on the human estrogen-responsive pS2 promoter Sewack, GF, Hansen, U	J. Biol. Chem.	1997