Reactome | CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

Stable Identifier

R-HSA-9009526

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

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CARM1 is an H3 R17 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003; Chen et al, 2000; Daujat et al, 2002). PRMT1 is an alternate arginine methyltransferase with activity toward H4 R3 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H3 R17 is not depicted.

Literature References

PubMed ID	Title	Journal	Year
12498683	Crosstalk between CARM1 methylation and CBP acetylation on histone H3 Daujat, S, Bauer, UM, Shah, V, Turner, B, Berger, S, Kouzarides, T	Curr. Biol.	2002
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F	Cell	2003
14631847	Acetylation and methylation in nuclear receptor gene activation Xu, W, Cho, H, Evans, RM	Meth. Enzymol.	2003
11010967	Synergistic, p160 coactivator-dependent enhancement of estrogen receptor function by CARM1 and p300 Chen, D, Huang, SM, Stallcup, MR	J. Biol. Chem.	2000