CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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CARM1 is an H3 R17 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003; Chen et al, 2000; Daujat et al, 2002). PRMT1 is an alternate arginine methyltransferase with activity toward H4 R3 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H3 R17 is not depicted.

Literature References
PubMed ID Title Journal Year
12498683 Crosstalk between CARM1 methylation and CBP acetylation on histone H3

Bauer, UM, Daujat, S, Shah, V, Kouzarides, T, Turner, B, Berger, S

Curr. Biol. 2002
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
14631847 Acetylation and methylation in nuclear receptor gene activation

Xu, W, Evans, RM, Cho, H

Meth. Enzymol. 2003
11010967 Synergistic, p160 coactivator-dependent enhancement of estrogen receptor function by CARM1 and p300

Huang, SM, Stallcup, MR, Chen, D

J. Biol. Chem. 2000
Orthologous Events
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