IL34:CSF1 binds CSF1R

Stable Identifier
R-HSA-9009485
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
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Summation

Interleukin-34 (IL34) can bind Macrophage colony-stimulating factor 1 (CSF1). The IL34:CSF1 heteromer may bind Macrophage colony-stimulating factor 1 receptor (CSF1R) facilitating receptor maturation and cellular trafficking. Consequently, downstream signaling pathways are activated (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The exact binding mechanism of IL34:CSF1 to CSF1R is unclear. Hence, this interaction is represented as a black box event.

Literature References
PubMed ID Title Journal Year
26095744 IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization

Ségaliny, AI, Brion, R, Brulin, B, Maillasson, M, Charrier, C, Téletchéa, S, Heymann, D

Cytokine 2015
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IL34:CSF1 binds CSF1R (Bos taurus)
IL34:CSF1 binds CSF1R (Canis familiaris)
IL34:CSF1 binds CSF1R (Gallus gallus)
IL34:CSF1 binds CSF1R (Mus musculus)
IL34:CSF1 binds CSF1R (Rattus norvegicus)
IL34:CSF1 binds CSF1R (Sus scrofa)
Authored
Varusai, TM  (2017-06-19)
Reviewed
Meldal, BH  (2017-11-03)