SMURF1 gene expression is stimulated by RUNX2

Stable Identifier
R-HSA-9009452
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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SMURF1 gene expression is stimulated by RUNX2
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Binding of RUNX2, presumably in complex with CBFB, to the SMURF1 gene promoter stimulates SMURF1 transcription. As SMURF1 is an E3 ubiquitin ligase which targets RUNX2 for degradation, this creates a negative feedback loop (Yang et al. 2014).
Literature References
PubMed ID Title Journal Year
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y

J Endod 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:SMURF1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)
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