Binding of RUNX2, presumably in complex with CBFB, to the SMURF1 gene promoter stimulates SMURF1 transcription. As SMURF1 is an E3 ubiquitin ligase which targets RUNX2 for degradation, this creates a negative feedback loop (Yang et al. 2014).
Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y
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