Binding of RUNX2, presumably in complex with CBFB, to the SMURF1 gene promoter stimulates SMURF1 transcription. As SMURF1 is an E3 ubiquitin ligase which targets RUNX2 for degradation, this creates a negative feedback loop (Yang et al. 2014).
Yang, F, Xu, N, Li, D, Guan, L, He, Y, Zhang, Y, Lu, Q, Zhang, X
© 2021 Reactome
