SMURF1 gene expression is stimulated by RUNX2

Stable Identifier
R-HSA-9009452
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMURF1 gene expression is stimulated by RUNX2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of RUNX2, presumably in complex with CBFB, to the SMURF1 gene promoter stimulates SMURF1 transcription. As SMURF1 is an E3 ubiquitin ligase which targets RUNX2 for degradation, this creates a negative feedback loop (Yang et al. 2014).

Literature References
PubMed ID Title Journal Year
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Yang, F, Xu, N, Li, D, Guan, L, He, Y, Zhang, Y, Lu, Q, Zhang, X

J Endod 2014
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)