SMURF1 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9009403
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, SMURF1 polyubiquitinates RUNX2, targeting it for degradation (Zhao et al. 2003). In human cells, RUNX2 ubiquitination is decreased upon SMURF1 knockdown (Yang et al. 2014).

Literature References
PubMed ID Title Journal Year
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Zhao, M, Qiao, M, Oyajobi, BO, Mundy, GR, Chen, D

J. Biol. Chem. 2003
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Yang, F, Xu, N, Li, D, Guan, L, He, Y, Zhang, Y, Lu, Q, Zhang, X

J Endod 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RUNX2:SMURF1 [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created