STUB1 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9009308
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
STUB1 polyubiquitinates RUNX2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STUB1 (CHIP), an E3 ubiquitin ligase, promotes polyubiquitination of RUNX2, targeting it for proteasome-mediated degradation (Li et al. 2008).

Literature References
PubMed ID Title Journal Year
18541707 CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Ren, F, Shi, Y, Zhai, Y, Irwin, DM, Li, X, Chang, Z, Shang, Y, Zheng, H, Huang, M, Chen, D, Wang, Y

J. Cell Biol. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of RUNX2:STUB1 [cytosol]

Physical Entity
RUNX2:STUB1 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
STUB1 polyubiquitinates RUNX2 (Bos taurus)
STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)
STUB1 polyubiquitinates RUNX2 (Canis familiaris)
STUB1 polyubiquitinates RUNX2 (Danio rerio)
STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)
STUB1 polyubiquitinates RUNX2 (Gallus gallus)
STUB1 polyubiquitinates RUNX2 (Mus musculus)
STUB1 polyubiquitinates RUNX2 (Sus scrofa)
STUB1 polyubiquitinates RUNX2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-06-16)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-16)
Cite Us!