Reactome | IL20 binds to IL22RA1:JAK1:IL20RB

IL20 binds to IL22RA1:JAK1:IL20RB

Stable Identifier

R-HSA-9009227

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-20 (IL20) (and Interleukin-24 (IL24)) can activate a complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB) (Dumoutier et al. 2001, Parrish-Novak et al. 2002). As it is not clear whether the receptor can form in the absence of ligand, association of the ligand with the receptor trimer is represented here as an uncertain event.

Literature References

PubMed ID	Title	Journal	Year
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W	J Biol Chem	2002