PTPNs gene transcription and translation

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser

Tyrosine protein phosphatase non receptors (PTPNs) are a family of enzymes that act in coordination with protein tyrosine kinases to control various signalling pathways downstream. This event represents the transcription and translation of the PTPN set comprising the members: 2, 4, 5, 6, 7, 9, 11, 12, 13, 14, 18, 20 and 23. This event is positively regulated by IL-37b(? 218):SMAD3 and promotes dephosphorylation and suppression of the activation of tyrosine phosphorylation-dependent signaling pathways such as ERK, p38 MAPK, JNK, PI3K, NF-?B, and STAT3 pathways. (Luo et al., 2017).

Literature References
PubMed ID Title Journal Year
28092676 Intracellular IL-37b interacts with Smad3 to suppress multiple signaling pathways and the metastatic phenotype of tumor cells

Luo, C, Shu, Y, Luo, J, Liu, D, Huang, DS, Han, Y, Chen, C, Li, YC, Zou, JM, Qin, J, Wang, Y, Li, D, Wang, SS, Zhang, GM, Chen, J, Feng, ZH

Oncogene 2017
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