RUNX2:CBFB binds BGLAP gene promoter

Stable Identifier
R-HSA-9008877
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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RUNX2:CBFB binds BGLAP gene promoter
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RUNX2 binds the OSE2 element in the promoter of the BGLAP (osteocalcin, OC) gene (Ducy and Karsenty 1995, Ducy et al. 1997). The affinity of the RUNX2:CBFB complex for the BGLAP gene promoter is increased when RUNX2 is phosphorylated on serine residue S451 (Wee et al. 2002), or on serine residues S294 and S312, which correspond to mouse Runx2-P1 residues S472, S301 and S319 (Ge et al. 2009). Formation of the complex between the activated androgen receptor (AR) and RUNX2 prevents RUNX2 from binding the BGLAP promoter (Baniwal et al. 2009). Twist proteins and Schnurri-3 also interact with RUNX2 to decrease BGLAP expression (Bialek et al. 2004, Jones et al. 2006). In contrast, RUNX2 and SATB2 interact to enhance the expression of osteoblast-specific genes (Dobreva et al. 2006).

Literature References
PubMed ID Title Journal Year
7891679 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

Ducy, P, Karsenty, G

Mol. Cell. Biol. 1995
19801668 Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor

Ge, C, Xiao, G, Jiang, D, Yang, Q, Hatch, NE, Roca, H, Franceschi, RT

J. Biol. Chem. 2009
19389811 Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA

Baniwal, SK, Khalid, O, Sir, D, Buchanan, G, Coetzee, GA, Frenkel, B

Mol. Endocrinol. 2009
9182762 Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

Ducy, P, Zhang, R, Geoffroy, V, Ridall, AL, Karsenty, G

Cell 1997
12231506 Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

Wee, HJ, Huang, G, Shigesada, K, Ito, Y

EMBO Rep. 2002
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2017-06-14)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-14)