PPM1D dephosphorylates RUNX2

Stable Identifier
R-HSA-9008822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PPM1D (Wip1), a serine/threonine phosphatase, dephosphorylates RUNX2 on serine residue S432. Since it has not been tested whether S432 affects bindng of RUNX2 to CBFB, PPM1D is shown to dephosphorylate RUNX2 in the context of its complex with CBFB. The kinase responsible for RUNX2 phosphorylation at S432 is not known. PPM1D-mediated dephosphorylation of RUNX2 promotes RUNX2-mediated transcriptional activation of BAX and may play an important role in inducing apoptosis in TP53 negative tumor cells (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References
PubMed ID Title Journal Year
22544321 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Goloudina, AR, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Cell Cycle 2012
22065775 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Goloudina, AR, Tanoue, K, Hammann, A, Fourmaux, E, le Guezennec, X, Bulavin, DV, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PPM1D [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created