Reactome | PPM1D dephosphorylates RUNX2

PPM1D dephosphorylates RUNX2

Stable Identifier

R-HSA-9008822

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PPM1D (Wip1), a serine/threonine phosphatase, dephosphorylates RUNX2 on serine residue S432. Since it has not been tested whether S432 affects bindng of RUNX2 to CBFB, PPM1D is shown to dephosphorylate RUNX2 in the context of its complex with CBFB. The kinase responsible for RUNX2 phosphorylation at S432 is not known. PPM1D-mediated dephosphorylation of RUNX2 promotes RUNX2-mediated transcriptional activation of BAX and may play an important role in inducing apoptosis in TP53 negative tumor cells (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22065775	Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents Goloudina, AR, Tanoue, K, Hammann, A, Fourmaux, E, le Guezennec, X, Bulavin, DV, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON	Proc. Natl. Acad. Sci. U.S.A.	2012
22544321	Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio Goloudina, AR, Mazur, SJ, Appella, E, Garrido, C, Demidov, ON	Cell Cycle	2012