IL37(?-218) translocates from the cytosol to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
IL-37(?-218) translocates from the cytosol to the nucleus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. The putative caspase 1 cleavage site is at aspartic acid 20 (Kumar et al. 2002). Truncated IL-37 can be translocated from the cytosol to the nucleus via a mechanism dependent on caspase 1 cleavage of IL-37 (Bulau A M et al. 2014). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

Literature References
PubMed ID Title Journal Year
24481253 Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Bulau, AM, Nold, MF, Li, S, Nold-Petry, CA, Fink, M, Mansell, A, Schwerd, T, Hong, J, Rubartelli, A, Dinarello, CA, Bufler, P

Proc. Natl. Acad. Sci. U.S.A. 2014
Participant Of
Orthologous Events
Cite Us!