Reactome | IL37, IL37(?-218) translocates from cytosol to extracellular region

IL37, IL37(?-218) translocates from cytosol to extracellular region

Stable Identifier

R-HSA-9008694

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region

Synonyms

IL-37, IL-37(?-218) translocates from cytosol to extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

IL37, IL37(?-218) translocates from cytosol to extracellular region

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. The putative caspase 1 cleavage site is at aspartic acid 20 (Kumar et al. 2002). Both full length and cleaved IL-37 can be secreted from the cytosol to the extracellular space via a mechanism dependent on caspase 1 cleavage of IL-37 (Bulau A M et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24481253	Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses Dinarello, CA, Bufler, P, Li, S, Rubartelli, A, Fink, M, Bulau, AM, Schwerd, T, Mansell, A, Nold, MF, Hong, J, Nold-Petry, CA	Proc. Natl. Acad. Sci. U.S.A.	2014