FBXW7 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9008479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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FBXW7 polyubiquitinates RUNX2
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The E3 ubiquitin ligase FBXW7alpha, a component of an SCF ubiquitin ligase complex, polyubiquitinates RUNX2, targeting it for degradation. The presence of GSK3B, and probably prior phosphorylation of RUNX2 by GSK3B, is required for FBXW7alpha-mediated polyubiquitination of RUNX2 (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
Participants
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hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of FBXW7alpha:SKP1:CUL1:RBX1:p-3S-RUNX2:GSK3B [nucleoplasm]
Physical Entity
FBXW7alpha:SKP1:CUL1:RBX1:p-3S-RUNX2:GSK3B [nucleoplasm]
Activity
ubiquitin protein ligase activity (0061630)
Inferred From
Fbxw7 polyubiquitinates Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-10)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-10)