FBXW7 polyubiquitinates RUNX2

Stable Identifier
R-HSA-9008479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FBXW7 polyubiquitinates RUNX2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The E3 ubiquitin ligase FBXW7alpha, a component of an SCF ubiquitin ligase complex, polyubiquitinates RUNX2, targeting it for degradation. The presence of GSK3B, and probably prior phosphorylation of RUNX2 by GSK3B, is required for FBXW7alpha-mediated polyubiquitination of RUNX2 (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Khan, K, Chattopadhyay, N, Shukla, N

J. Biol. Chem. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of FBXW7alpha:SKP1:CUL1:RBX1:p-3S-RUNX2:GSK3B [nucleoplasm]

Physical Entity
FBXW7alpha:SKP1:CUL1:RBX1:p-3S-RUNX2:GSK3B [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
Fbxw7 polyubiquitinates Runx2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-10)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-10)
Cite Us!