The E3 ubiquitin ligase FBXW7alpha, a component of an SCF ubiquitin ligase complex, polyubiquitinates RUNX2, targeting it for degradation. The presence of GSK3B, and probably prior phosphorylation of RUNX2 by GSK3B, is required for FBXW7alpha-mediated polyubiquitination of RUNX2 (Kumar et al. 2015).
Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Khan, K, Chattopadhyay, N, Shukla, N
ubiquitin protein ligase activity of FBXW7alpha:SKP1:CUL1:RBX1:p-3S-RUNX2:GSK3B [nucleoplasm]
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