The E3 ubiquitin ligase FBXW7alpha, a component of an SCF ubiquitin ligase complex, polyubiquitinates RUNX2, targeting it for degradation. The presence of GSK3B, and probably prior phosphorylation of RUNX2 by GSK3B, is required for FBXW7alpha-mediated polyubiquitination of RUNX2 (Kumar et al. 2015).
Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK
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