FBXW7 binds RUNX2 and GSK3B

Stable Identifier
R-HSA-9008478
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FBXW7alpha, a component of an SCF ubiquitin ligase complex, binds to RUNX2 in the presence of GSK3B, probably after GSK3B phosphorylates RUNX2 (Kumar et al. 2015). The presence of other SCF complex components, besides FBXW7alpha, is assumed, although it has not been tested whether they co-immunoprecipitate with RUNX2 and GSK3B.

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
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