RUNX2 binds GSK3B

Stable Identifier
R-HSA-9008476
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX2 forms a complex with a serine/threonine kinase GSK3B. Since GSK3B can localize to both cytosol and nucleus, this reaction is shown to occur in the nucleoplasm, although this has not been experimentally tested (Kugimiya et al. 2007, Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
17786208 GSK-3beta controls osteogenesis through regulating Runx2 activity

Kugimiya, F, Kawaguchi, H, Ohba, S, Kawamura, N, Hirata, M, Chikuda, H, Azuma, Y, Woodgett, JR, Nakamura, K, Chung, UI

PLoS ONE 2007
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