Reactome | CDKN1A gene expression is inhibited by RUNX2

CDKN1A gene expression is inhibited by RUNX2

Stable Identifier

R-HSA-9008456

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CDKN1A gene expression is inhibited by RUNX2

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Binding of RUNX2 to the CDKN1A gene promoter inhibits CDKN1A transcription, thus preventing CDKN1A-induced cell cycle arrest. Phosphorylation of RUNX2 by CDK4 in response to high glucose enhances RUNX2-mediated repression of the CDKN1A gene in endothelial cells (Pierce et al. 2012). HDAC6, which forms a complex with RUNX2, may contribute to RUNX2-mediated repression of CDKN1A in developing osteoblasts (Westendorf et al. 2002). In mice, Runx2-mediated repression of Cdkn1a may contribute to the development of acute myeloid leukemia (AML) (Kuo et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12391164	Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter van Wijnen, AJ, Kahler, R, Cascino, JE, Zaidi, SK, Yoshida, M, Lian, JB, Westendorf, JJ, Li, X, Stein, GS	Mol. Cell. Biol.	2002
21913213	Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype Mochin, MT, Pierce, AD, Passaniti, A, Kommineni, S, Vitolo, MI, Goldblum, SE, Anglin, IE, Underwood, KF	J. Cell. Biochem.	2012