RUNX2 binds CDKN1A gene promoter

Stable Identifier
R-HSA-9008433
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX2 binds CDKN1A gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RUNX2, presumably in complex with at least CBFB, binds to at least two of the three RUNX2-binding sites in the promoter of the CDKN1A (p21) gene. CDK4-mediated phosphorylation of RUNX2 enhances binding of RUNX2 to the CDKN1A promoter (Pierce et al. 2012). The complex of RUNX2 and HDAC6 is also implicated in regulation of the CDKN1A promoter (Westendorf et al. 2002).
Literature References
PubMed ID Title Journal Year
21913213 Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype

Pierce, AD, Anglin, IE, Vitolo, MI, Mochin, MT, Underwood, KF, Goldblum, SE, Kommineni, S, Passaniti, A

J. Cell. Biochem. 2012
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2017-06-09)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-09)
Cite Us!