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p-S465-RUNX2-P1 [nucleoplasm]
Stable Identifier
R-HSA-9008409
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S465-RUNX2-distal
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
CDK1 phosphorylates RUNX2 (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
CDK4 phosphorylates RUNX2 (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm] (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
RUNX2 binds CDKN1A gene promoter (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm] (Homo sapiens)
(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB):BGLAP gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB,p-S451-RUNX2:CBFB,(p-2S-RUNX2:CBFB) [nucleoplasm] (Homo sapiens)
p-S451-RUNX2:CBFB [nucleoplasm] (Homo sapiens)
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
p-S465-RUNX2-P1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13950-1 RUNX2
Gene Names
RUNX2, AML3, CBFA1, OSF2, PEBP2A
Other Identifiers
11725180_a_at
11738448_a_at
17009289
216994_PM_s_at
216994_s_at
221282_PM_x_at
221282_x_at
232231_PM_at
232231_at
236858_PM_s_at
236858_s_at
236859_PM_at
236859_at
2908763
2908764
2908765
2908766
2908767
2908768
2908771
2908772
2908773
2908774
2908775
2908782
2908783
2908785
2908804
2908810
2908820
2908822
2908823
2908829
2908830
2908831
2908832
2908833
2908834
34501_at
34502_g_at
39187_at
53261_at
73682_at
8120043
860
A_14_P119973
A_14_P200868
A_24_P69267
A_32_P148058
A_32_P161762
A_33_P3316508
GE57763
GE746159
GE862488
GE87963
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001501
GO:0001503
GO:0001649
GO:0001958
GO:0002051
GO:0002062
GO:0002063
GO:0002076
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0007224
GO:0008283
GO:0008284
GO:0010467
GO:0010468
GO:0010628
GO:0019904
GO:0030097
GO:0030154
GO:0030182
GO:0030217
GO:0030278
GO:0030282
GO:0030509
GO:0031490
GO:0032332
GO:0035115
GO:0036076
GO:0040036
GO:0042475
GO:0042487
GO:0043226
GO:0043425
GO:0045595
GO:0045667
GO:0045669
GO:0045879
GO:0045892
GO:0045893
GO:0045944
GO:0048469
GO:0048701
GO:0048705
GO:0048856
GO:0048863
GO:0050673
GO:0050679
GO:0051094
GO:0060395
GO:0072089
GO:0140110
GO:0140297
GO:1904383
GO:1990837
GO:2000648
HMNXSV003005224
HMNXSV003013710
HMNXSV003025019
Hs.122116.0.A1_3p_at
Hs.50115.0.S1_3p_at
ILMN_1669066
ILMN_1716651
ILMN_2377746
L40992_at
PH_hs_0006824
PH_hs_0038735
TC06000621.hg
g10863884_3p_a_at
Participates
as a member of
p-S451-RUNX2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RUNX2-P1 [nucleoplasm]
RUNX2-P1 [cytosol]
p-S294,S312-RUNX2-P1 [nucleoplasm]
PolyUb-RUNX2-P1 [nucleoplasm]
PolyUb-RUNX2-P1 [cytosol]
p-S294,S298,S302-RUNX2-P1 [nucleoplasm]
p-S432-RUNX2-P1 [nucleoplasm]
p-S196,T198,T200-RUNX2-P1 [nucleoplasm]
Inferred To
phospho-RunxB [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-S465-RUNX2-P1 [nucleoplasm]
(Drosophila melanogaster)
phospho-run [nucleoplasm]
(Drosophila melanogaster)
phospho-Runx2 [nucleoplasm]
(Mus musculus)
phospho-lz [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S465-RUNX2-P1 [nucleoplasm]
(Bos taurus)
phospho-p-S465-RUNX2-P1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S465-RUNX2-P1 [nucleoplasm]
(Gallus gallus)
phospho-RUNX2 [nucleoplasm]
(Canis familiaris)
phospho-RUNX2 [nucleoplasm]
(Sus scrofa)
phospho-RunxA [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001015051.3
,
NP_001019801.3
OpenTargets
ENSG00000124813
ENSEMBL
ENSP00000495497
,
ENSP00000360491
,
ENSP00000360493
,
ENST00000371432
,
ENST00000647337
,
ENST00000371436
,
ENSP00000352514
,
ENST00000371438
,
ENSP00000360486
,
ENST00000359524
HPA
ENSG00000124813-RUNX2
PRO
Q13950
Pharos - Targets
Q13950
Orphanet
RUNX2
GlyGen
Q13950
PDB
6VGD
,
6VGE
,
6VGG
,
6VG8
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.602
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.591
7
UniProt:P17480 UBTF
2
UBTF [nucleoplasm]
(R-HSA-73683)
p-UBTF [nucleoplasm]
(R-HSA-76039)
0.564
4
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.527
3
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