RUNX2 binds HDAC4

Stable Identifier
R-HSA-9008326
Type
Reaction [binding]
Species
Homo sapiens
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Based on studies in mice, RUNX2 forms a complex with the histone deacetylase HDAC4. The interaction involves the Runt DNA binding domain of RUNX2 and leads to inhibition of RUNX2 binding to its target DNA sequences. Specifically, interference with RUNX2 binding to the RUNX2 promoter in the presence of HDAC4 has been demonstrated. Hdac4 knockout mice develop premature ossification of developing bones because of premature and ectopic onset of chondrocyte hypertrophy. This phenotype is similar to the Runx2 overexpression phenotype in mouse chondrocytes (Vega et al. 2004).

Literature References
PubMed ID Title Journal Year
15537544 Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

Vega, RB, Matsuda, K, Oh, J, Barbosa, AC, Yang, X, Meadows, E, McAnally, J, Pomajzl, C, Shelton, JM, Richardson, JA, Karsenty, G, Olson, EN

Cell 2004
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