Reactome | TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen

TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen

Stable Identifier

R-HSA-9008315

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen

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The TGFA gene encodes the precursor of the transforming growth factor alpha (TGF alpha). Binding of the CITED1 to the promoter of the TGFA gene in the estrogen:ESR1-dependent manner stimulates TGFA transcription in MCF-7 breast cancer cell line (Yahata T et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11581164	Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein Shioda, T, Brown, M, Kato, S, Endoh, H, Coser, KR, Isselbacher, KJ, Hur, J, Yahata, T, Sun, H, Shao, W, Ueda, Y	Genes Dev.	2001