Reactome | CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter

CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter

Stable Identifier

R-HSA-9008271

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter

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CITED1 and EP300 contribute to the estrogen-dependent expression of the TGFA gene. CITED1 (also known as CBP) interacts directly with ESR1 through the transcriptional activation AF2 domain and enhances its activity. The interaction between ESR1 and exogenous CITED1 also stabilizes the interaction with EP300 (Yahate et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11581164	Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein Yahata, T, Shao, W, Endoh, H, Hur, J, Coser, KR, Sun, H, Ueda, Y, Kato, S, Isselbacher, KJ, Brown, M, Shioda, T	Genes Dev.	2001