NCOA1 is a nuclear receptor coactivator that is recruited to the TGFA promoter through direct interaction with ESR1 (Halachmi et al, 1994; Cavaillès et al, 1994; Harnstein et al, 2001). Although NCOA1 has intrinsic histone acetyltransferase activity, it plays a more predominant role in activating gene transcription through its ability to recruit EP300 to the promoter (Harnstein et al, 2001; reviewed in Arnal el al, 2017).
Parker, MG, Dauvois, S, Danielian, PS, Cavaillès, V
Halachmi, S, Brown, M, Martin, G, Marden, E, MacKay, H, Abbondanza, C
Brown, M, Hanstein, B, DiRenzo, J, Eckner, R, Searcy, B, Kurokawa, R, Liu, H, Halachmi, S
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