Reactome | NCOA1 binds ESR1:estrogen:TGFA gene

NCOA1 binds ESR1:estrogen:TGFA gene

Stable Identifier

R-HSA-9008270

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NCOA1 is a nuclear receptor coactivator that is recruited to the TGFA promoter through direct interaction with ESR1 (Halachmi et al, 1994; Cavaillès et al, 1994; Harnstein et al, 2001). Although NCOA1 has intrinsic histone acetyltransferase activity, it plays a more predominant role in activating gene transcription through its ability to recruit EP300 to the promoter (Harnstein et al, 2001; reviewed in Arnal el al, 2017).

Literature References

PubMed ID	Title	Journal	Year
7937828	Interaction of proteins with transcriptionally active estrogen receptors Cavaillès, V, Dauvois, S, Danielian, PS, Parker, MG	Proc. Natl. Acad. Sci. U.S.A.	1994
8197458	Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription Halachmi, S, Marden, E, Martin, G, MacKay, H, Abbondanza, C, Brown, M	Science	1994
8876171	p300 is a component of an estrogen receptor coactivator complex Hanstein, B, Eckner, R, DiRenzo, J, Halachmi, S, Liu, H, Searcy, B, Kurokawa, R, Brown, M	Proc. Natl. Acad. Sci. U.S.A.	1996