Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PolyUb-RUNX2-P2 [nucleoplasm]
Stable Identifier
R-HSA-9008124
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PolyUb-RUNX2-proximal
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
PolyUb-RUNX2 [nucleoplasm] (Homo sapiens)
PolyUb-RUNX2-P2 [nucleoplasm] (Homo sapiens)
SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)
PolyUb-RUNX2 [nucleoplasm] (Homo sapiens)
PolyUb-RUNX2-P2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13950-2 RUNX2
Gene Names
RUNX2, AML3, CBFA1, OSF2, PEBP2A
Other Identifiers
11725180_a_at
11738448_a_at
17009289
216994_PM_s_at
216994_s_at
221282_PM_x_at
221282_x_at
232231_PM_at
232231_at
236859_PM_at
236859_at
2908763
2908764
2908765
2908766
2908767
2908768
2908774
2908775
2908782
2908783
2908785
2908804
2908810
2908820
2908822
2908823
34501_at
34502_g_at
53261_at
8120043
860
A_14_P119973
A_14_P200868
A_24_P69267
A_32_P161762
A_33_P3316508
GE57763
GE87963
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001501
GO:0001503
GO:0001649
GO:0001958
GO:0002051
GO:0002062
GO:0002063
GO:0002076
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007224
GO:0008283
GO:0008284
GO:0010467
GO:0010468
GO:0010628
GO:0019904
GO:0023052
GO:0030097
GO:0030154
GO:0030182
GO:0030217
GO:0030278
GO:0030282
GO:0030509
GO:0031490
GO:0032332
GO:0035115
GO:0036076
GO:0040036
GO:0042475
GO:0042487
GO:0043226
GO:0043425
GO:0045595
GO:0045667
GO:0045669
GO:0045879
GO:0045892
GO:0045893
GO:0045944
GO:0048469
GO:0048701
GO:0048705
GO:0048856
GO:0048863
GO:0050673
GO:0050679
GO:0051094
GO:0060395
GO:0072089
GO:0140110
GO:0140297
GO:1904383
GO:1990837
GO:2000648
HMNXSV003005224
HMNXSV003013710
HMNXSV003025019
Hs.122116.0.A1_3p_at
Hs.50115.0.S1_3p_at
ILMN_1669066
ILMN_1716651
ILMN_2377746
L40992_at
PH_hs_0006824
PH_hs_0038735
TC06000621.hg
g10863884_3p_a_at
Participates
as a candidate of
PolyUb-RUNX2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S182,T184,T186-RUNX2-P2 [nucleoplasm]
p-S280,S284,S288-RUNX2-P2 [nucleoplasm]
PolyUb-RUNX2-P2 [cytosol]
RUNX2-P2 [nucleoplasm]
RUNX2-P2 [cytosol]
p-S451-RUNX2-P2 [nucleoplasm]
p-S280,S298-RUNX2-P2 [nucleoplasm]
p-S418-RUNX2-P2 [nucleoplasm]
Inferred To
RUNX2 [nucleoplasm]
(Canis familiaris)
RUNX2 [nucleoplasm]
(Sus scrofa)
run [nucleoplasm]
(Drosophila melanogaster)
Runx2 [nucleoplasm]
(Mus musculus)
Homologues of PolyUb-RUNX2-P2 [nucleoplasm]
(Drosophila melanogaster)
RunxB [nucleoplasm]
(Drosophila melanogaster)
PolyUb-RUNX2-P2 [nucleoplasm]
(Bos taurus)
PolyUb-RUNX2-P2 [nucleoplasm]
(Caenorhabditis elegans)
PolyUb-RUNX2-P2 [nucleoplasm]
(Danio rerio)
PolyUb-RUNX2-P2 [nucleoplasm]
(Gallus gallus)
PolyUb-RUNX2-P2 [nucleoplasm]
(Xenopus tropicalis)
lz [nucleoplasm]
(Drosophila melanogaster)
RunxA [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position
Modification
polyubiquitin chain [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001019801.3
,
NP_001015051.3
OpenTargets
ENSG00000124813
HPA
ENSG00000124813-RUNX2
GeneCards
Q13950
Ensembl
ENST00000371438
,
ENSG00000124813
,
ENST00000371432
,
ENSP00000495497
,
ENSP00000352514
,
ENST00000359524
,
ENSP00000360493
,
ENSP00000360491
,
ENSP00000360486
,
ENST00000371436
,
ENST00000647337
PRO
Q13950
Pharos - Targets
Q13950
Orphanet
15236
PDB
6VG8
,
6VGD
,
6VGG
,
6VGE
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.602
4
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.591
7
UniProt:P17480 UBTF
2
p-UBTF [nucleoplasm]
(R-HSA-76039)
UBTF [nucleoplasm]
(R-HSA-73683)
0.564
4
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.527
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text