Reactome | IL1F10 binds IL1RAPL1

IL1F10 binds IL1RAPL1

Stable Identifier

R-HSA-9008054

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interleukins are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 1 family member 10 (IL1F10, IL 38) is a member of the IL1 family (Lin et al. 2001, Bensen et al. 2001 IL1F10 is produced in Human apoptotic cells (Mora et al. 2016) and human epidermal keratinocytes (based on mRNA studies) (Boutet M A et al. 2016). Full length (1 – 152 amino acids) IL1F10 can bind Interleukin 1 receptor accessory protein like 1 (IL1RAPL1) (Mora et al. 2016). N-terminally truncated IL1F10 (20 – 152 amino acids) is also known to bind IL1RAPL1 but with much higher affinity. The physiological significance of full length IL1F10 binding to IL1RAPL1 is not known.

Literature References

PubMed ID	Title	Journal	Year
26892022	Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses Weigert, A, Putyrski, M, Frank, AC, Wittig, I, Brüne, B, Schlemmer, A, Han, Y, Ernst, A, Jung, M, Richter, F, Mora, J	J Mol Cell Biol	2016