RUNX2 translocates to the nucleus

Stable Identifier
R-HSA-9007999
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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RUNX2 translocates to the nucleus
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Based on studies in mice, binding of RUNX2 to cytosolic STAT1 inhibits RUNX2 translocation to the nucleus (Kim et al. 2003).
Literature References
PubMed ID Title Journal Year
12923053 Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

Kim, S, Koga, T, Isobe, M, Kern, BE, Yokochi, T, Chin, YE, Karsenty, G, Taniguchi, T, Takayanagi, H

Genes Dev. 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX2:STAT1 [cytosol] (Homo sapiens)
Active Unit
STAT1 [cytosol]
Inferred From
Runx2 translocates to the nucleus (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-06)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-06)
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