Reactome | IL1F10 binds IL1RL2

IL1F10 binds IL1RL2

Stable Identifier

R-HSA-9007901

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interleukins are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 1 family member 10 (IL1F10, IL 38) is a member of the IL1 family (Lin et al. 2001, Bensen et al. 2001). IL1F10 is produced in Human apoptotic cells (Mora et al. 2016) and human epidermal keratinocytes (based on mRNA studies) (Boutet M A et al. 2016). IL1F10 can bind to interleukin 1 receptor like 2 (IL1RL2, IL 36R, IL1Rrp2, IL1R6). This binding has biological consequences similar to another IL1RL2 ligand IL 36 receptor antagonist (IL 36Ra), such as suppression of IL17 and IL22 and induction of IL6 production (van de Veerdonk et al. 2012, Mora et al. 2016). Ultimately, these events lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

Literature References

PubMed ID	Title	Journal	Year
22315422	IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist van de Veerdonk, FL, Stoeckman, AK, Wu, G, Boeckermann, AN, Azam, T, Netea, MG, Joosten, LA, van der Meer, JW, Hao, R, Kalabokis, V, Dinarello, CA	Proc. Natl. Acad. Sci. U.S.A.	2012
26892022	Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses Mora, J, Schlemmer, A, Wittig, I, Richter, F, Putyrski, M, Frank, AC, Han, Y, Jung, M, Ernst, A, Weigert, A, Brüne, B	J Mol Cell Biol	2016