RUNX2 binds HAND2

Stable Identifier
R-HSA-9007816
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, RUNX2 binds to the basic helix-loop-helix (bHLH) protein HAND2. The interaction involves the N-terminal part of HAND2 and the Runt DNA binding domain of RUNX2. Interaction with HAND2 prevents binding of RUNX2 to the DNA, thus inhibiting transcriptional activation of RUNX2 target genes. HAND1 is also able to bind to RUNX2 and inhibit binding of RUNX2 to the DNA, but this interaction is not considered to be physiologically relevant as RUNX2 and HAND1 are not coexpressed in vivo, and targeted deletion of Hand1 in mice does not lead to skeletal defects. Mice hypomorphic for a mutant Hand2 allele, however, show abnormal membranous bone phenotype, accompanied with elevated Runx2 expression and precocious and accelerated osteoblast differentiation (Funato et al. 2009).

In mouse tissues, Hand2 expression is also associated with Runx2 downregulation (Funato et al. 2009, Barron et al. 2011). This could be due to the suggested Hand2-mediated transcriptional repression of Dlx5 and Dlx6, two transcription factors involved in stimulation of Runx2 expression (Barron et al. 2011).

Literature References
PubMed ID Title Journal Year
19144722 Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

Funato, N, Chapman, SL, McKee, MD, Funato, H, Morris, JA, Shelton, JM, Richardson, JA, Yanagisawa, H

Development 2009
Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!