MSX2 binds RUNX2 gene promoter

Stable Identifier
R-HSA-9007759
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MSX2 binds RUNX2 gene promoter
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Based on studies in mice, homeobox transcription factor MSX2 binds to DLX5 sites in the distal (P1) promoter of the RUNX2 gene, which are conserved between mice and humans, and antagonizes DLX5 binding (Lee et al. 2005).

Literature References
PubMed ID Title Journal Year
16115867 Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

Choi, KY, Lee, MH, Cho, JY, Wozney, JM, Hwang, YS, Kim, YJ, Choi, JY, Bae, SC, Ryoo, HM, Chi, XZ, Kim, BG, Kim, JI, Yoon, WJ

J. Biol. Chem. 2005
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Msx2 binds Runx2 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-03)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-03)
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