MSX2 binds RUNX2 gene promoter

Stable Identifier
R-HSA-9007759
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, homeobox transcription factor MSX2 binds to DLX5 sites in the distal (P1) promoter of the RUNX2 gene, which are conserved between mice and humans, and antagonizes DLX5 binding (Lee et al. 2005).
Literature References
PubMed ID Title Journal Year
16115867 Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

Choi, KY, Lee, MH, Cho, JY, Wozney, JM, Hwang, YS, Kim, YJ, Choi, JY, Bae, SC, Ryoo, HM, Chi, XZ, Kim, BG, Kim, JI, Yoon, WJ

J. Biol. Chem. 2005
Participants
Participates
Inferred From
Authored
Reviewed
Created
Cite Us!