Based on studies in mice, transcription of RUNX2 from the distal (P1) promoter is directly stimulated by DLX5 (and possibly DLX6). Binding of DLX5 to the RUNX2 promoter is antagonized by MSX2. Once bound to the RUNX2 promoter, MSX2 inhibits RUNX2 transcription (Lee et al. 2005). DLX5 is activated by BMP2 signaling through an unknown mechanism.Transcription of RUNX2 from the P1 promoter may be inhibited by the transcriptional repressor GFI1, which is essential for hematopoiesis (D'Souza et al. 2011).
Li, X, Robledo, RF, Rajan, L, Lufkin, T
Choi, KY, Lee, MH, Cho, JY, Wozney, JM, Hwang, YS, Kim, YJ, Choi, JY, Bae, SC, Ryoo, HM, Chi, XZ, Kim, BG, Kim, JI, Yoon, WJ
Jones, S, Luc, Q, Stein, JL, Stein, GS, Choi, JY, Neil, JC, Hu, M, Van Wijnen, AJ, Terry, A, Drissi, H, Shakoori, R, Chuva De Sousa Lopes, S, Lian, JB
van Wijnen, AJ, Lengner, CJ, Lian, JB, Stein, JL, Stein, GS, Lepper, C, Hassan, MQ, Serra, RW
Lassar, AB, Kim, DW, Kronenberg, HM, Kempf, H, Chyung, J, Murtaugh, LC, Chung, UI, Provot, S
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