RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6

Stable Identifier
R-HSA-9007582
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6
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Transcription of the RAD51 gene is directly stimulated by E2F1 (Wu et al. 2014) and inhibited by E2F6 (Bertoli et al. 2013).
Literature References
PubMed ID Title Journal Year
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, Klier, S, McGowan, C, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
24627085 Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia

Wu, M, Wang, X, McGregor, N, Pienta, KJ, Zhang, J

Mol. Pharmacol. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F6:(TFDP1,TFDP2) [nucleoplasm]
Positively by
Regulator
E2F1:(TFDP1,TFDP2):RAD51 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:(TFDP1,TFDP2) [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-06-01)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-31)
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