Reactome | UXT gene expression is repressed by the PRC1L4 complex

UXT gene expression is repressed by the PRC1L4 complex

Stable Identifier

R-HSA-9007465

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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UXT gene expression is repressed by the PRC1L4 complex

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Binding of the PRC1L4 complex, composed of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2 and RING1 or RNF2, to the UXT gene promoter represses UXT transcription. This is concluded based on experimental evidence of direct association of the PRC1L4 complex with the UXT gene promoter and increased UXT expression upon E2F6 or L3MBTL2 knockdown (Trojer et al. 2011). E2F6 was also reported as a repressor of the UXT gene transcription by Oberley et al. 2013.

Literature References

PubMed ID	Title	Journal	Year
21596310	L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure Trojer, P, Cao, AR, Gao, Z, Li, Y, Zhang, J, Xu, X, Li, G, Losson, R, Erdjument-Bromage, H, Tempst, P, Farnham, PJ, Reinberg, D	Mol. Cell	2011
12909625	E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 Oberley, MJ, Inman, DR, Farnham, PJ	J. Biol. Chem.	2003