UXT gene expression is repressed by the PRC1L4 complex

Stable Identifier
R-HSA-9007465
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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UXT gene expression is repressed by the PRC1L4 complex
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Binding of the PRC1L4 complex, composed of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2 and RING1 or RNF2, to the UXT gene promoter represses UXT transcription. This is concluded based on experimental evidence of direct association of the PRC1L4 complex with the UXT gene promoter and increased UXT expression upon E2F6 or L3MBTL2 knockdown (Trojer et al. 2011). E2F6 was also reported as a repressor of the UXT gene transcription by Oberley et al. 2013.
Literature References
PubMed ID Title Journal Year
12909625 E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9

Oberley, MJ, Inman, DR, Farnham, PJ

J. Biol. Chem. 2003
21596310 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Trojer, P, Cao, AR, Gao, Z, Li, Y, Zhang, J, Xu, X, Li, G, Losson, R, Erdjument-Bromage, H, Tempst, P, Farnham, PJ, Reinberg, D

Mol. Cell 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PRC1L4:UXT gene [nucleoplasm] (Homo sapiens)
Active Unit
PRC1L4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-06-01)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-31)
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