Binding of the PRC1L4 complex, composed of E2F6, CBX3 (HP1gamma), PCGF6 (MBLR), L3MBTL2 and RING1 or RNF2, to the UXT gene promoter represses UXT transcription. This is concluded based on experimental evidence of direct association of the PRC1L4 complex with the UXT gene promoter and increased UXT expression upon E2F6 or L3MBTL2 knockdown (Trojer et al. 2011). E2F6 was also reported as a repressor of the UXT gene transcription by Oberley et al. 2013.
Inman, DR, Oberley, MJ, Farnham, PJ
Trojer, P, Gao, Z, Reinberg, D, Losson, R, Farnham, PJ, Xu, X, Li, Y, Li, G, Cao, AR, Zhang, J, Tempst, P, Erdjument-Bromage, H
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