E2F6 forms the PRC1L4 complex

Stable Identifier
R-HSA-9007447
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E2F6 forms the PRC1L4 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F6 forms a complex with CBX3 (HP1gamma) and components of the polycomb repressor complex PRC1.6: PCGF6 (MBLR), L3MBTL2, RING1 (RING1A) or RNF2 (RING2, also known as RING2B). This polycomb repressor-like complex is named PRC1L4. Unlike the complex composed of E2F6.com-1, PRC1.6 and CBX3 (Ogawa et al. 2002), the PRC1L4 complex does not possess histone methyltransferase activity. Instead, the PRC1L4 complex may have a histone E3-ubiquitin ligase activity. The PRC1L4 complex was shown to bind to promoters of several genes: CDC7, CSTF3, MCM3, UXT, RPA2, RAD51C, RFC3, HOXC5. Of these genes, transcriptional repression was tested and demonstrated for CDC7 and UXT (Trojer et al. 2011).
Literature References
PubMed ID Title Journal Year
21596310 L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

Trojer, P, Gao, Z, Reinberg, D, Losson, R, Farnham, PJ, Xu, X, Li, Y, Li, G, Cao, AR, Zhang, J, Tempst, P, Erdjument-Bromage, H

Mol. Cell 2011
Participants
Input
Output
Participates
as an event of
Orthologous Events
E2F6 forms the PRC1L4 complex (Bos taurus)
E2F6 forms the PRC1L4 complex (Canis familiaris)
E2F6 forms the PRC1L4 complex (Drosophila melanogaster)
E2F6 forms the PRC1L4 complex (Gallus gallus)
E2F6 forms the PRC1L4 complex (Mus musculus)
E2F6 forms the PRC1L4 complex (Rattus norvegicus)
E2F6 forms the PRC1L4 complex (Sus scrofa)
Authored
Orlic-Milacic, M  (2017-06-01)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-30)
Cite Us!