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RING1,RNF2 [nucleoplasm]
Stable Identifier
R-HSA-9007201
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RING1A,RING1B
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:CDC7 gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.6 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
E2F6 forms the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:CDC7 gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:UXT gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1L4:UXT gene [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
RING1,RNF2 [nucleoplasm] (Homo sapiens)
Participants
members
RING1 [nucleoplasm]
(Homo sapiens)
RNF2 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
PRC1 complex [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
PRC1.6 [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
as an input of
E2F6 forms the PRC1L4 complex (Homo sapiens)
Inferred To
RNF2 [nucleoplasm]
(Gallus gallus)
spat-3 [nucleoplasm]
(Caenorhabditis elegans)
RING1,RNF2 [nucleoplasm]
(Bos taurus)
RING1,RNF2 [nucleoplasm]
(Canis familiaris)
RING1,RNF2 [nucleoplasm]
(Mus musculus)
RING1,RNF2 [nucleoplasm]
(Rattus norvegicus)
RING1,RNF2 [nucleoplasm]
(Sus scrofa)
RING1,RNF2 [nucleoplasm]
(Xenopus tropicalis)
rnf2 [nucleoplasm]
(Danio rerio)
Sce [nucleoplasm]
(Drosophila melanogaster)
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