IL21 receptor JAK phosphorylation

Stable Identifier
R-HSA-9006850
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The IL21 heteromeric receptor complex can activate JAK1 and JAK3 in response to Interleukin-21 (IL21), leading to JAK tyrosine phosphorylation (Asao et al. 2001, Habib et al. 2002).

This is a black box event because the mechanism leading to JAK phosphorylation is not established for this receptor complex.

Literature References
PubMed ID Title Journal Year
11418623 Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K

J. Immunol. 2001
12093291 The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K

Biochemistry 2002
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