PTPN4 gene expression is stimulated by MECP2

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R-HSA-9006585
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Reaction [omitted]
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Homo sapiens
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Binding of MECP2 to the PTPN4 gene promoter stimulates PTPN4 transcription. PTPN4 gene encodes a protein tyrosine phosphatase, non-receptor type, also known as MEG, PTPase-MEG1 or PTPMEG. Expression of Ptpn4 is reduced in Mecp2 null mice used as a Rett syndrome model. A hemizygous PTPN4 gene deletion was found in twins with a Rett-like phenotype (Williamson et al. 2015).

Literature References
PubMed ID Title Journal Year
25424712 Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

Williamson, SL, Ellaway, CJ, Peters, GB, Pelka, GJ, Tam, PP, Christodoulou, J

Eur. J. Hum. Genet. 2015
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