PVALB gene expression is repressed by MECP2

Stable Identifier
R-HSA-9006508
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PVALB gene expression is repressed by MECP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, binding of MECP2 to the promoter of the PVALB gene represses PVALB transcription. Pvalb levels are increased in visual cortical neurons of Mecp2 knockout mice, which is thought to contribute to visual regression (Durand et al. 2012).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:PVALB gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Pvalb gene expression is repressed by Mecp2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-16)
Cite Us!