Reactome | p-T320-MeCP2_e1 [nucleoplasm]

p-T320-MeCP2_e1 [nucleoplasm]

Stable Identifier

R-HSA-9005592

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-T320-MECP2B

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 is phosphorylated at T308 (Homo sapiens)
        
        p-T308-MECP2 [nucleoplasm] (Homo sapiens)
        
        p-T320-MeCP2_e1 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15034579	A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome Friez, MJ, Vincent, JB, Schanen, NC, Alfred, SE, Scherer, SW, Jones, JR, Munteanu, I, MacLeod, PJ, Lohi, H, Yamada, T, Mnatzakanian, GN, Minassian, BA	Nat. Genet.	2004

External Reference Information

External Reference

UniProt:P51608-2 MECP2

Gene Names

MECP2

Other Identifiers

11722682_at

11722683_a_at

11722684_a_at

17115428

17115453

202616_PM_s_at

202616_s_at

202617_PM_s_at

202617_s_at

202618_PM_s_at

202618_s_at

34355_at

4027023

4027024

4027025

4027026

4027027

4027028

4027029

4027030

4027031

4027032

4027033

4027034

4027035

4027036

4027037

4027038

4027039

4027040

4027041

4027042

4027043

4027044

4027045

4027046

4027047

4027048

4027049

4027050

4027051

4027052

4027053

4027055

4027057

4027058

4027059

4027060

4027061

4027062

4027080

4027081

4027090

4027091

4027092

4204

8175977

8175998

A_23_P114361

A_24_P237486

A_33_P3317211

A_33_P3339036

GE54240

GO:0000122

GO:0000400

GO:0000785

GO:0000792

GO:0001662

GO:0001666

GO:0001964

GO:0001976

GO:0002087

GO:0003013

GO:0003016

GO:0003676

GO:0003677

GO:0003682

GO:0003714

GO:0003723

GO:0003729

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005975

GO:0006020

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006520

GO:0006541

GO:0006576

GO:0006629

GO:0007010

GO:0007018

GO:0007219

GO:0007268

GO:0007416

GO:0007420

GO:0007507

GO:0007585

GO:0007612

GO:0007613

GO:0007616

GO:0008104

GO:0008211

GO:0008283

GO:0008306

GO:0008327

GO:0008344

GO:0008542

GO:0009791

GO:0010212

GO:0010288

GO:0010385

GO:0010467

GO:0010468

GO:0010628

GO:0010629

GO:0012501

GO:0014003

GO:0014009

GO:0014070

GO:0016358

GO:0016525

GO:0019230

GO:0019233

GO:0019899

GO:0019904

GO:0021510

GO:0021549

GO:0021591

GO:0021740

GO:0021756

GO:0021766

GO:0021772

GO:0021794

GO:0021987

GO:0023052

GO:0030154

GO:0030182

GO:0031047

GO:0031175

GO:0031490

GO:0031507

GO:0031915

GO:0032048

GO:0032355

GO:0032991

GO:0033555

GO:0034330

GO:0035176

GO:0035197

GO:0035865

GO:0036211

GO:0040029

GO:0042220

GO:0042551

GO:0042802

GO:0042826

GO:0043226

GO:0043524

GO:0043537

GO:0044027

GO:0044030

GO:0045322

GO:0045892

GO:0045893

GO:0045944

GO:0046470

GO:0048167

GO:0048286

GO:0048709

GO:0048712

GO:0048856

GO:0048870

GO:0050432

GO:0050807

GO:0050877

GO:0050884

GO:0050905

GO:0051151

GO:0051570

GO:0051707

GO:0060079

GO:0060090

GO:0060252

GO:0060291

GO:0060999

GO:0061000

GO:0065003

GO:0071317

GO:0071514

GO:0090063

GO:0090327

GO:0098794

GO:0098978

GO:0099191

GO:0099611

GO:0140110

GO:0140566

GO:0140693

GO:1901953

GO:1901956

GO:1903860

GO:1903861

GO:1903941

GO:1905492

GO:1990841

GO:2000635

HMNXSV003006762

HMNXSV003039744

HMNXSV003048644

Hs.3239.0.S2_3p_a_at

ILMN_1702715

PH_hs_0000399

TC0X001524.hg

X89430_at

X94628_rna1_s_at

g7710148_3p_a_at

g972764_3p_a_at

Participates

as a candidate of

p-T308-MECP2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MECP2_e1 R145C [nucleoplasm]

MECP2_e1 D133G [nucleoplasm]

MECP2_e1 R145H [nucleoplasm]

MECP2_e1 R118W [nucleoplasm]

MECP2_e1 T170A [nucleoplasm]

MECP2_e1 T170M [nucleoplasm]

MECP2_e1 S144F [nucleoplasm]

MeCP2_e1 K317R [nucleoplasm]

MeCP2_e1 P314R [nucleoplasm]

MeCP2_e1 K316E [nucleoplasm]

MeCP2_e1 R318C [nucleoplasm]

MeCP2_e1 R318H [nucleoplasm]

MECP2_e1 [nucleoplasm]

p-S92-MECP2_e1 [nucleoplasm]

p-S435-MECP2_e1 [nucleoplasm]

Modified Residues

Name

O-phospho-L-threonine at 320

Coordinate

320

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001303266.1, NP_001104262.1, NP_004983.1

OpenTargets

ENSG00000169057

GeneCards

P51608

HPA

ENSG00000169057-MECP2

Ensembl

ENSP00000395535, ENST00000453960, ENST00000303391, ENSP00000301948, ENSG00000169057

PRO

P51608

Pharos - Targets

P51608

Orphanet

16388

PDB

5BT2, 1QK9, 8AJR, 3C2I, 6OGJ, 8ALQ, 6OGK, 6C1Y, 6YWW

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.591	4
UniProt:Q9QXE7 Tbl1x	2	Tbl1x [nucleoplasm] (R-MMU-2064253) Tbl1x [nucleoplasm] (R-MMU-351644)	0.591	3
UniProt:Q9QZR5	3	monoSUMO1-K32-HIPK2 [nucleoplasm] (R-MMU-4090405) HIPK2 [nucleoplasm] (R-MMU-3215222) phospho-p-HIPK2 [nucleoplasm] (R-MMU-6799375)	0.581	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.564	2
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	3
UniProt:Q9BZK7 TBL1XR1	1	TBL1XR1 [nucleoplasm] (R-HSA-351643)	0.527	3
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	3
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	3
UniProt:Q8WVM0 TFB1M	1	TFB1M [mitochondrial matrix] (R-HSA-1592207)	0.527	2
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.527	2
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	3
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.527	2
UniProt:Q96RR1 TWNK	1	TWNK [mitochondrial matrix] (R-HSA-1592222)	0.527	3
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	3
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:Q9WU42 Ncor2	3	monoSumo1-K668-Ncor2 [nucleoplasm] (R-MMU-3927907) Ncor2 [nucleoplasm] (R-MMU-442511) Ncor2 [nucleoplasm] (R-MMU-442469)	0.525	4
UniProt:Q8BHJ5 Tbl1xr1	1	Tbl1xr1 [nucleoplasm] (R-MMU-2064254)	0.525	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.499	2

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