Phosphorylated Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 1 alpha/beta (STAT1) dissociate from the Interleukin-24 (IL24) receptor complex (Wang et al. 2002). This complex is formed by IL24 ligand, phosphorylated Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2007). This is a black box event because dissociation is inferred to occur to allow STAT dimerization and translocation to the nucleus, as is the case for STAT3 activation by the Interleukin-10 receptor (Niemand et al. 2003).
Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA
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