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IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
Stable Identifier
R-HSA-8987266
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IFNL1 can induce phosphorylation of Signal transducer and activator of transcription 1 alpha/beta (STAT1), Signal transducer and activator of transcription 2 (STAT2) , Signal transducer and activator of transcription 3 (STAT3) , Signal transducer and activator of transcription 4 (STAT4) ,Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004, Novak et al. 2008), Signal transducer and activator of transcription 2 (STAT2)(Dickensheets et al. 2013), Signal transducer and activator of transcription 4 (STAT4) and Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004). This is a black-box event because direct evidence for STAT4 and 5-binding and activation is lacking. STAT binding is inferred from subsequent phosphorylation in response to IFNL1 (Jordan et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
18830264
A role for IFN-lambda1 in multiple myeloma B cell growth
Rajkumar, V
,
Ziesmer, SC
,
Novak, AJ
,
Doyle, SE
,
Grote, DM
,
Ansell, SM
Leukemia
2008
Participants
Input
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
(Homo sapiens)
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol]
(Homo sapiens)
Output
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-20 family signaling (Homo sapiens)
Orthologous Events
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)
Authored
Duenas, C (2017-03-16)
Reviewed
Datta, SK (2017-11-15)
Created
Duenas, C (2017-05-05)
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