IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3

Stable Identifier
R-HSA-8987255
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT1,STAT3 are phosphorylated by IL26:IL10RB:p‑TYK2:IL20RA:p‑JAK1:STAT1, STAT1 is phosphorylated by IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1 activated receptor complex., STAT1 is phosphorylated after IL26:IL26Receptor interaction
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Signal transducer and activator of transcription 1 alpha/beta (STAT1) or Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated by the Interleukin 26 (IL26) receptor complex,which consists of IL26, Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2), Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) (Sheikh et al. 2004), STAT1 and STAT3.
This is a black box event since there is no direct evidence that STAT1 or STAT3 bind the receptor complex before being phosphorylated, but this can be inferred from the signaling mechanism of other related interleukin receptors such as IL10 (Weber-Nordt et al. 1996, Braum et al. 2013).

Literature References
PubMed ID Title Journal Year
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Sheikh, F, Baurin, VV, Lewis-Antes, A, Shah, NK, Smirnov, SV, Anantha, S, Dickensheets, H, Dumoutier, L, Renauld, JC, Zdanov, A, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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