Reactome | IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3

IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3

Stable Identifier

R-HSA-8987220

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

JAK2, JAK3 binds IL20:IL20RA:JAK1:IL20RB receptor complex, JAK2,JAK3 binds IL20-IL20 receptor complex

ReviewStatus

5/5

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Tyrosine-protein kinase JAK2 (JAK2) or Tyrosine-protein kinase JAK3 (JAK3) are believed to bind the complex formed by Interleukin-20 (IL20), Interleukin-20 Receptor subunit alpha (IL20RA), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB). JAK2 was phosphorylated in response to IL20 in porcine aorta endothelial cells (Tritsaris et al. 2007). JAK2 and JAK3 were phosphorylated after IL20 stimulation of human 253J bladder cancer cells (Lee et al. 2012).

This is a black box event since it is unclear whether JAK2/3 are constitutively associated or bind to the receptor after IL20 stimulation.

Literature References

PubMed ID	Title	Journal	Year
17878297	IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs Tritsaris, K, Myren, M, Ditlev, SB, Hübschmann, MV, van der Blom, I, Hansen, AJ, Olsen, UB, Cao, R, Zhang, J, Jia, T, Wahlberg, E, Dissing, S, Cao, Y	Proc. Natl. Acad. Sci. U.S.A.	2007
22962576	Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A Lee, SJ, Lee, EJ, Kim, SK, Jeong, P, Cho, YH, Yun, SJ, Kim, S, Kim, GY, Choi, YH, Cha, EJ, Kim, WJ, Moon, SK	PLoS ONE	2012